2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137565
    Hydroxy ritonavir
    		99.60%
    Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
    Hydroxy ritonavir
  • HY-141530
    Clopidogrel-β-D-glucuronide
    Clopidogrel-β-D-glucuronide is a metabolite of Clopidogrel (HY-15283). Clopidogrel-β-D-glucuronide directly interacts with CYP2C8 enzyme and strongly inhibits the liver enzyme CYP2C8.
    Clopidogrel-β-D-glucuronide
  • HY-101723
    Modecainide
    		99.36%
    Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.
    Modecainide
  • HY-137963
    Daidzein 4'-β-D-glucuronide
    Daidzein 4'-β-D-glucuronide (Compound M4) is a metabolite of Daidzein (HY-N0019).
    Daidzein 4'-β-D-glucuronide
  • HY-137522A
    Zidovudine O-β-D-glucuronide
    Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
    Zidovudine O-β-D-glucuronide
  • HY-138166
    Rosuvastatin lactone
    Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor).
    Rosuvastatin lactone
  • HY-130465
    7α-Thiospironolactone
    		99.85%
    7α-Thiospironolactone is the transformation product of spironolactone (HY-B0561), which can be obtained by the metabolism of Thermomyces lanuginosus.
    7α-Thiospironolactone
  • HY-133675
    Mono(5-carboxy-2-ethylpentyl) phthalate
    Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(5-carboxy-2-ethylpentyl) phthalate
  • HY-123349
    5α-Hydroxy-6-keto cholesterol
    		≥99.0%
    5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM.
    5α-Hydroxy-6-keto cholesterol
  • HY-W008216S
    HMMNI-d3
    		99.90%
    HMMNI-d3 (Hydroxy Dimetridazole-d3) is deuterium labeled HMMNI (HY-W008216). HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazol (HY-B1244). Dimetridazole is a nitroimidazole class agent that combats protozoan infections.
    HMMNI-d<sub>3</sub>
  • HY-136456
    2-NP-AMOZ
    2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
    2-NP-AMOZ
  • HY-135385
    Dihydro Dutasteride
    		99.72%
    Dihydro Dutasteride is a metabolite of Dutasteride. Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.
    Dihydro Dutasteride
  • HY-W002112S
    (±)-Nornicotine-d4
    		≥98.0%
    (±)-Nornicotine-d4 is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
    (±)-Nornicotine-d<sub>4</sub>
  • HY-N0384R
    Homovanillic acid (Standard)
    Homovanillic acid (Standard) is the analytical standard of Homovanillic acid. This product is intended for research and analytical applications. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
    Homovanillic acid (Standard)
  • HY-136346
    2-Hydroxy atorvastatin lactone
    2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
    2-Hydroxy atorvastatin lactone
  • HY-12781
    Desbutyl Lumefantrine
    		99.66%
    Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.
    Desbutyl Lumefantrine
  • HY-W019773
    Albendazole sulfone
    Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
    Albendazole sulfone
  • HY-100646
    (E)-10-Hydroxynortriptyline maleate
    (E)-10-Hydroxynortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (E)-10-Hydroxynortriptyline maleate
  • HY-109564
    5α-Pregnane-3β,6α-diol-20-one
    		≥98.0%
    5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.
    5α-Pregnane-3β,6α-diol-20-one
  • HY-131272
    Febuxostat dicarboxylic acid impurity
    		98.76%
    Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat dicarboxylic acid impurity
Cat. No. Product Name / Synonyms Application Reactivity